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Complex I inhibitors, such as IACS-010759 and BAY87-2243, have demonstrated potent efficacy in preclinical models of CRC subtypes with high OXPHOS dependence [143]

439 This trial investigated the efficacy of SG in advanced TNBC patients with at least two prior treatments, and SG significantly improved PFS and OS compared with physicians choices

This is due to its many health benefits, including its anti-inflammatory, antioxidant, and possibly modulating effects on oestrogen hormone receptor signalling or the stimulation of DNA repair pathways

Lung tissue was processed as follows: one portion was immediately frozen in liquid nitrogen and stored at 80 C for gene expression analysis